NFKB1基因編碼功能及結構描述
該基因編碼一個105kd蛋白，該蛋白可以通過26s蛋白酶體進行共翻譯處理，產生一個50kd蛋白。105kd蛋白是Rel蛋白特異性轉錄抑制劑，50kd蛋白是NF-kappa-B（NFKB）蛋白復合物的DNA結合亞基NFKB是一種轉錄調節因子，通過細胞內、細胞外的刺激，如細胞因子、氧化自由基、紫外線照射和細菌或病毒產物激活。激活的nfkb轉運到細胞核中，刺激參與多種生物學功能的基因表達。nfkb的不適當激活與許多炎癥性疾病有關，而nfkb的持續抑制導致免疫細胞發育不適當或細胞生長延遲。選擇性剪接導致編碼不同亞型的多個轉錄變體，其中至少一個是經過蛋白質水解處理的[由RefSeq提供，2016年2月]
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]
